化工社化工社 化学情報印刷レポート · 研究参考用
Iodine → (R)-3-((tetrahydrofuran-2-yl)methyl)-3,4,6,7-tetrahydro-2H-pyrano[3,4-d]thiazol-2-imine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | 2H-Pyran-3(4H)-one, dihydro- | HCID 90109 | — |
| 反応物 | Potassium thiocyanate | HCID 516872 | — |
| 反応物 | (R)-(-)-Tetrahydrofurfurylamine | HCID 2734124 | — |
| 生成物 | (R)-3-((tetrahydrofuran-2-yl)methyl)-3,4,6,7-tetrahydro-2H-pyrano[3,4-d]thiazol-2-imine | HCID 68622205 | — |
反応手順
Commercially available dihydro-2H-pyran-3(4H)-one (Small Molecules Inc), (R)-(tetrahydrofuran-2-yl)methanamine (Aldrich), potassium thiocyanate (Aldrich) and iodine (Aldrich) were processed using the method described in Example 315A to afford the title compound. LCMS (ESI+) m/z 241 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841334B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-69eff5169c93463e927402e2406d5bf8 |
| 出典メモ | uspto-grants-2014_09 |