Iodine → 5-tert-butyl-3-(2-((cis)-2,6-dimethylmorpholino)ethyl)thiazol-2(3H)-imine

HRID 78533

反応式

HRID 78533 の反応式
[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH:4]=O.[NH2:8][CH2:9][CH2:10][N:11]1[CH2:16][C@H:15]([CH3:17])[O:14][C@H:13]([CH3:18])[CH2:12]1.[S-:19][C:20]#[N:21].[K+].II>>[C:2]([C:3]1[S:19][C:20](=[NH:21])[N:8]([CH2:9][CH2:10][N:11]2[CH2:16][C@@H:15]([CH3:17])[O:14][C@@H:13]([CH3:18])[CH2:12]2)[CH:4]=1)([CH3:7])([CH3:6])[CH3:1]

参加物

5

反応物 4

HCID 807IodineHCID 763353,3-DimethylbutanalHCID 516872Potassium thiocyanateHCID 71449682-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-amine

生成物 1

HCID 686236405-tert-butyl-3-(2-((cis)-2,6-dimethylmorpholino)ethyl)thiazol-2(3H)-imine

実験手順

Commercially available 3,3-dimethylbutanal (Aldrich), 4-(2-aminoethyl)-cis-2,6-dimethylmorpholine (Oakwood), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 315A to afford the title compound. MS (ESI+) m/z 298 (M+H)+.

出典と根拠

ORDレコード
ord-36fc5c9db0d84a059829a33d35f48c22
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

関連ノート

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