Iodine → 5-tert-butyl-3-(2-((cis)-2,6-dimethylmorpholino)ethyl)thiazol-2(3H)-imine
反応式
[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH:4]=O.[NH2:8][CH2:9][CH2:10][N:11]1[CH2:16][C@H:15]([CH3:17])[O:14][C@H:13]([CH3:18])[CH2:12]1.[S-:19][C:20]#[N:21].[K+].II>>[C:2]([C:3]1[S:19][C:20](=[NH:21])[N:8]([CH2:9][CH2:10][N:11]2[CH2:16][C@@H:15]([CH3:17])[O:14][C@@H:13]([CH3:18])[CH2:12]2)[CH:4]=1)([CH3:7])([CH3:6])[CH3:1]参加物
5
実験手順
Commercially available 3,3-dimethylbutanal (Aldrich), 4-(2-aminoethyl)-cis-2,6-dimethylmorpholine (Oakwood), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 315A to afford the title compound. MS (ESI+) m/z 298 (M+H)+.
出典と根拠
- ORDレコード
- ord-36fc5c9db0d84a059829a33d35f48c22
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841334B2
反応ノート
読み込み中…