Propargyl bromide → 4,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide
反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[C:10]#[CH:11]>C1(C)C=CC=CC=1.C(OCC)C>[BrH:12].[CH3:1][C:2]1[N:3]([CH2:11][C:10]#[CH:9])[C:4](=[NH:8])[S:5][C:6]=1[CH3:7]参加物
5
反応条件
- 温度
- 85 °C
実験手順
To a solution of 4,5-dimethylthiazol-2-amine (2.5 g, 19.5 mmol) in 10 mL toluene was added propargyl bromide (2.78 g, 23.4 mmol). The reaction was heated at 85° C. for 12 h then cooled. The crude material was diluted with diethyl ether and the solid was collected via filtration to give 3.5 g of the title compound which was used without further purification. m/z 167.1 (M+H)+.
後処理
- temperaturethen cooled
- filtrationthe solid was collected via filtration
出典と根拠
- ORDレコード
- ord-b6f5b5843ebb4d588a2e5b6422eff13e
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841334B2
反応ノート
読み込み中…