Propargyl bromide → 4,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide

HRID 78534

反応式

HRID 78534 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[C:10]#[CH:11]>C1(C)C=CC=CC=1.C(OCC)C>[BrH:12].[CH3:1][C:2]1[N:3]([CH2:11][C:10]#[CH:9])[C:4](=[NH:8])[S:5][C:6]=1[CH3:7]

参加物

5

反応物 2

HCID 7842Propargyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

生成物 1

HCID 866408574,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide収率 72.6%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

反応条件

温度
85 °C

実験手順

To a solution of 4,5-dimethylthiazol-2-amine (2.5 g, 19.5 mmol) in 10 mL toluene was added propargyl bromide (2.78 g, 23.4 mmol). The reaction was heated at 85° C. for 12 h then cooled. The crude material was diluted with diethyl ether and the solid was collected via filtration to give 3.5 g of the title compound which was used without further purification. m/z 167.1 (M+H)+.

後処理

  1. temperaturethen cooled
  2. filtrationthe solid was collected via filtration

出典と根拠

ORDレコード
ord-b6f5b5843ebb4d588a2e5b6422eff13e
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

関連ノート

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