Sodium Hydroxide → 6-amino-1-(2-isocyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

HRID 78688

反応式

HRID 78688 の反応式
[C:1]([CH2:3][C:4]([N:6]([CH3:19])[C:7](=[O:18])[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]#[C-:17])=[O:5])#[N:2].[OH-].[Na+]>O>[NH2:2][C:1]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N+:16]#[C-:17])[C:7](=[O:18])[N:6]([CH3:19])[C:4](=[O:5])[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 580761243-(2-Cyano-acetyl)-3-methyl-1-(2-isocyanobenzyl)-urea

生成物 1

HCID 580761306-amino-1-(2-isocyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione収率 76%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

To 3-(2-cyano-acetyl)-3-methyl-1-(2-isocyanobenzyl)-urea (120 g) were added water (962 ml) and 2N aqueous sodium hydroxide solution (24.9 ml), and the mixture was stirred with heating at 80° C. for 1 hr. After allowing to cool to room temperature, the crystals were collected by filtration and dried to give 6-amino-1-(2-isocyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione in 76% yield.

後処理

  1. temperatureto cool to room temperature
  2. filtrationthe crystals were collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-d2c9a2f934174f18adb1d70e52b96ecf
出典データセット
uspto-grants-2014_09
特許番号
US08841447B2

関連ノート

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