Sodium Sulfite → Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate
反応式
[CH2:1]([O:3][C:4](=[O:16])[C:5]([C:7]1(Br)[CH2:11][CH2:10][O:9][CH:8]1[O:12][CH2:13][CH3:14])=[O:6])[CH3:2].S([O-])([O-])=O.[Na+].[Na+]>ClCCl>[CH2:1]([O:3][C:4](=[O:16])[C:5]([CH:7]1[CH2:11][CH2:10][O:9][CH:8]1[O:12][CH2:13][CH3:14])=[O:6])[CH3:2]参加物
4
実験手順
Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (100 g) dissolved in dichloromethane (500 ml). Sodium sulphite solution (15%, 1000 ml) was added to it. Reaction mass was stirred for 8 hrs. Organic and aqueous layer separated dichloromethane layer was washed with water (2×200 ml). Dichloromethane layer was then concentrated to residue to get Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 67 g)
後処理
- customReaction mass
- customOrganic and aqueous layer separated dichloromethane layer
- washwas washed with water (2×200 ml)
- concentrationDichloromethane layer was then concentrated to residue
出典と根拠
- ORDレコード
- ord-1c0b3c08f3254dceba8884123e9da8d8
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841467B2
反応ノート
読み込み中…