Cis-3-azido-6-benzhydryl-tetrahydropyran → Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine

HRID 78900ノート

反応式

HRID 78900 の反応式
[N:1]([C@H:4]1[CH2:9][CH2:8][C@@H:7]([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:6][CH2:5]1)=[N+]=[N-]>CO.[Pd]>[CH:10]([C@H:7]1[O:6][CH2:5][C@@H:4]([NH2:1])[CH2:9][CH2:8]1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 11630718Cis-3-azido-6-benzhydryl-tetrahydropyran

生成物 1

HCID 11565229Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine収率 78%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Cis-5-azido-2-diphenylmethyl-tetrahydropyran 14 (0.3 g, 1.02 mmol) in methanol (25 ml) was hydrogenated under the catalyst of 10% Pd—C (0.03 g, 10% wt) for 4 hr (Procedure C) to give cis-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.21 g, 78%) as an oil.

出典と根拠

ORDレコード
ord-71b10c7887a54c0da9c25d008c71bb77
出典データセット
uspto-grants-2014_09
特許番号
US08841464B2

反応ノート

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