1-((6-methoxypyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole → 3-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-amine

HRID 79297

反応式

HRID 79297 の反応式
[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH2:9][N:10]2[C:18]3[C:13](=[C:14]([N+:19]([O-])=O)[CH:15]=[CH:16][CH:17]=3)[C:12]([CH:22]=[CH2:23])=[N:11]2)[CH:6]=[CH:5][CH:4]=1>CO.[OH-].[OH-].[Pd+2]>[CH2:22]([C:12]1[C:13]2[C:14]([NH2:19])=[CH:15][CH:16]=[CH:17][C:18]=2[N:10]([CH2:9][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=2)[N:11]=1)[CH3:23]

参加物

4

反応物 1

HCID 672600471-((6-methoxypyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole

生成物 1

HCID 672592283-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-amine収率 79.1%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

To 1-((6-methoxypyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole (1.89 g, 6.09 mmol) in MeOH (60 mL) was added Pd(OH)2/C (20 wt %, 400 mg). The reaction mixture was purged with N2 and charge with H2 (45 psi). The reaction mixture was recharged H2 to 45 psi after 45 minute. The reaction was stopped after 5 hours. The reaction mixture was filtered through Celite®, washed with MeOH (200 mL) and concentrated to provide the desired product (1.36 g).

後処理

  1. customThe reaction mixture was purged with N2
  2. additioncharge with H2 (45 psi)
  3. customafter 45 minute
  4. filtrationThe reaction mixture was filtered through Celite®
  5. washwashed with MeOH (200 mL)
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-a228aba76530405ab6f4c68bf6c1a722
出典データセット
uspto-grants-2014_09
特許番号
US08841455B2

関連ノート

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