Hydrochloric Acid → HCID 178437935、化合物

HRID 79302

反応式

HRID 79302 の反応式
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([O:31]C)[N:26]=2)[N:4]=1)[CH3:2].Cl.C([O-])(O)=O.[Na+]>C1COCC1>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([OH:31])[N:26]=2)[N:4]=1)[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 67259608N-(3-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

生成物 1

HCID 178437935HCID 178437935、化合物収率 97.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

To N-(3-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (210 mg, 0.492 mmol) in THF (6 mL) was added hydrochloric acid (4M in dioxane, 2 mL). The reaction vial was sealed, heated to 80° C. and stirred for 24 hours. The reaction was cooled to ambient temperature and saturated NaHCO3 aqueous solution was added until pH=7. THF and H2O were removed under reduced pressure. The resulting solid was washed with H2O (20 mL) and dried under vacuum to provide the desired product (198 mg).

後処理

  1. customThe reaction
  2. customvial was sealed
  3. temperatureThe reaction was cooled to ambient temperature
  4. customTHF and H2O were removed under reduced pressure
  5. washThe resulting solid was washed with H2O (20 mL)
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-c5e7b3ae1473447abe4cc9c132cd542a
出典データセット
uspto-grants-2014_09
特許番号
US08841455B2

関連ノート

読み込み中…