Tetrahydrofuran → HCID 86672213、化合物

HRID 79361ノート

反応式

HRID 79361 の反応式
[CH3:1][O:2][C:3]1[N:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+].[CH2:37]1COC[CH2:38]1>>[CH2:37]([CH:5]([C:4]1[C:3]([O:2][CH3:1])=[N:12][C:11]([CH3:13])=[CH:10][CH:9]=1)[OH:7])[CH3:38]

参加物

5

反応物 4

HCID 8028Tetrahydrofuran2 回HCID 62649Sodium sulfate decahydrateHCID 10910170METHYL 2-METHOXY-6-METHYLPYRIDINE-3-CARBOXYLATEHCID 21226445Aluminium lithium hydride

生成物 1

HCID 86672213HCID 86672213、化合物

反応条件

温度
0 °C

実験手順

To methyl 2-methoxy-6-methylnicotinate (5.60 g, 30.9 mmol) in THF (155 mL, 30.9 mmol) to 0° C. was added lithium aluminum hydride (1.23 g, 30.9 mmol) and the mixture was stirred at 0° C. for 75 minutes. The mixture was diluted with 30 mL THF and a scoop of Celite was added. The mixture was stirred for a few minutes. Sodium sulfate decahydrate was added to quench the reaction. The mixture was filtered and the filtrate was concentrated to give the product (4.7 g).

後処理

  1. additiona scoop of Celite was added
  2. stirringThe mixture was stirred for a few minutes
  3. customto quench
  4. customthe reaction
  5. filtrationThe mixture was filtered
  6. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-a20c86094b5b4575acd71a23ee8ea2fb
出典データセット
uspto-grants-2014_09
特許番号
US08841455B2

反応ノート

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