Thionyl Chloride → 3-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride

HRID 79394ノート

反応式

HRID 79394 の反応式
[CH:1]([N:4]1[CH:8]=[CH:7][C:6]([CH2:9]O)=[N:5]1)([CH3:3])[CH3:2].S(Cl)([Cl:13])=O>C(Cl)Cl>[ClH:13].[Cl:13][CH2:9][C:6]1[CH:7]=[CH:8][N:4]([CH:1]([CH3:3])[CH3:2])[N:5]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 23005538(1-(propan-2-yl)-1H-pyrazol-3-yl)methanol

生成物 1

HCID 672599053-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride収率 85.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (1-isopropyl-1H-pyrazol-3-yl)methanol (3.45 g, 24.61 mmol) in DCM (50 mL) was added thionyl chloride (5.386 mL, 73.83 mmol) at ambient temperature. The mixture was allowed to stir at ambient temperature for 18 hours. The mixture was concentrated under vacuum to afford 3-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride (4.1 g, 85% yield) as a yellow gum.

後処理

  1. concentrationThe mixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-e169da713b8f4be4a67f53fa164ab8a4
出典データセット
uspto-grants-2014_09
特許番号
US08841455B2

反応ノート

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