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1H-1,2,4-Triazole → N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-(1H-1,2,4-triazol-1-yl)imidazo[1,2-a]pyridine-3-carboxamide

HRID 79435
ノート
印刷プレビュー

反応式

HRID 79435 の反応式
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[H-].[Na+].[CH2:8]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[NH:19][C:20]([C:22]2[N:26]3[CH:27]=[CH:28][C:29](F)=[CH:30][C:25]3=[N:24][CH:23]=2)=[O:21])[N:12]([CH2:32][C:33]2[CH:37]=[CH:36][N:35]([CH2:38][CH3:39])[N:34]=2)[N:11]=1)[CH3:9]>C1OCCOC1.CN(C)C=O>[CH2:8]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[NH:19][C:20]([C:22]2[N:26]3[CH:27]=[CH:28][C:29]([N:1]4[CH:5]=[N:4][CH:3]=[N:2]4)=[CH:30][C:25]3=[N:24][CH:23]=2)=[O:21])[N:12]([CH2:32][C:33]2[CH:37]=[CH:36][N:35]([CH2:38][CH3:39])[N:34]=2)[N:11]=1)[CH3:9]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 92571H-1,2,4-TriazoleHCID 24758Sodium hydrideHCID 67259540N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-fluoroimidazo[1,2-a]pyridine-3-carboxamide

生成物 1

HCID 67259791N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-(1H-1,2,4-triazol-1-yl)imidazo[1,2-a]pyridine-3-carboxamide

試薬・触媒・溶媒 2

HCID 6228
Dimethylformamide
溶媒
HCID 312751,4-Dioxane溶媒

実験手順

1H-1,2,4-triazole was dissolved in 4-dioxane and treated with sodium hydride (20 mg, 0.48 mmol, 60% dispersion in mineral oil) with stirring at ambient temperature for 30 minutes. N-(3-Ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-fluoroimidazo[1,2-a]pyridine-3-carboxamide (35 mg, 0.08 mmol) was added as a solution in N,N-dimethylformamide. The mixture was heated to 98° C. and stirred for 2 days. The mixture was quenched by the addition of water. A precipitate formed and the solid was isolated by filtration, washed with water and dried under vacuum to give N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-(1H-1,2,4-triazol-1-yl)imidazo[1,2-a]pyridine-3-carboxamide as a white solid (39 mg). MS m/z 481.1 (M+1, APCI+).

後処理

  1. temperatureThe mixture was heated to 98° C.
  2. stirringstirred for 2 days
  3. customThe mixture was quenched by the addition of water
  4. customA precipitate formed
  5. customthe solid was isolated by filtration
  6. washwashed with water
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-1f8068529cd949d78e37560e39bb2b71
出典データセット
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08841455B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート