HCID 68762213、化合物 → HCID 68761562、化合物

反応式

C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]3[NH:20][CH:21]=[C:22]([NH:23][C:24](=[O:28])[CH2:25][CH2:26][CH3:27])[C:15]=23)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.Cl.[Pd]>[N:11]1([C:14]2[CH:19]=[CH:18][N:17]=[C:16]3[NH:20][CH:21]=[C:22]([NH:23][C:24](=[O:28])[CH2:25][CH2:26][CH3:27])[C:15]=23)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

参加物

実験手順

N-(4-(4-Benzylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)butyramide (0.070 g, 0.19 mmol) was dissolved in MeOH (1 mL). Pd/C (0.0197 g, 0.0185 mmol) was then added, followed by the addition of 3 drops of concentrated HCl. The reaction was then placed under a H2 balloon for 18 hours. The reaction was then filtered, washed with MeOH, and concentrated to give the crude product N-(4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)butyramide (0.050 g, 93.8% yield).