Thionyl Chloride → 6-Bromo-2-naphthoyl chloride

反応式

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.S(Cl)([Cl:17])=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:17])=[O:14])[CH:6]=[CH:5]2

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 45498526-Bromo-2-naphthalenecarboxylic acid

生成物 1

HCID 218796066-Bromo-2-naphthoyl chloride

反応条件

温度: 60 °C

実験手順

6-Bromonaphthalene-2-carboxylic acid (25.1 g) was suspended in thionyl chloride (200 mL), stirred at 60° C. for 16 hours and evaporated under vacuum. Solid was dissolved in dichloromethane (50 mL) and evaporated under vacuum, giving 6-bromonaphthalene-2-carbonyl chloride (27.0 g, crude) as a white solid.

後処理

customevaporated under vacuum
dissolutionSolid was dissolved in dichloromethane (50 mL)
customevaporated under vacuum

出典と根拠

ORDレコード: ord-422fdddf97b24433a87ab0303052734e
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08841278B2

反応ノート

読み込み中…

参加物