1-Methylpiperazine → 2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-[4-(methylsulfonyl)phenyl]-2H-pyridazin-3-one

HRID 8001ノート

反応式

HRID 8001 の反応式
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:15](=[O:33])[N:16]([CH2:29][CH:30]([CH3:32])[CH3:31])[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][C:24](C)=[C:23](F)[CH:22]=3)[C:19]=2[CH3:20])[CH2:10][CH2:9]1)=O)(C)(C)C.C(N1C(=O)C(C[O:46][S:47]([CH3:50])(=O)=[O:48])=CC(C2C=CC(S(C)(=O)=O)=CC=2)=N1)C(C)C.CN1CCNCC1>>[CH2:29]([N:16]1[C:15](=[O:33])[C:14]([N:11]2[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]2)=[C:19]([CH3:20])[C:18]([C:21]2[CH:26]=[CH:25][C:24]([S:47]([CH3:50])(=[O:48])=[O:46])=[CH:23][CH:22]=2)=[N:17]1)[CH:30]([CH3:32])[CH3:31]

参加物

4

反応物 3

HCID 531671-MethylpiperazineHCID 219915242-isobutyl-4-methanesulfonyloxymethyl-6-[4-(methylsulfonyl)phenyl]-2H-pyridazin-3-oneHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

生成物 1

HCID 219916292-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-[4-(methylsulfonyl)phenyl]-2H-pyridazin-3-one収率 88.5%

実験手順

Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxymethyl-6-[4-(methylsulfonyl)phenyl]-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 88.5%).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-b3423afc01ca486a9a249ab1a15b1858
出典データセット
uspto-grants-2006_08
特許番号
US07087606B2

反応ノート

読み込み中…