反応式
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11](CO)C(=O)N(CC(C)C)N=1.[F:22][C:23]1[CH:24]=[C:25]([C:31]2[CH:32]=[C:33]([C:38]([O:40][CH3:41])=[O:39])[C:34](=[O:37])[NH:35][N:36]=2)[CH:26]=[CH:27][C:28]=1[O:29][CH3:30].S([O-])(=O)(=O)C.FC1C=CC(CCCO)=CC=1>>[F:22][C:23]1[CH:24]=[C:25]([C:31]2[CH:32]=[C:33]([C:38]([O:40][CH3:41])=[O:39])[C:34](=[O:37])[N:35]([CH2:11][CH2:10][CH2:9][C:3]3[CH:2]=[CH:7][C:6]([F:8])=[CH:5][CH:4]=3)[N:36]=2)[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]参加物
5
反応物 4
生成物 1
実験手順
Following the procedure of Example 1 (6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and the mesylate derivative of 3-(4-fluorophenyl)-1-propanol {J. Med. Chem., 19, 461 (1976)} were reacted to yield the title compound as a yellow oil (yield: 90.1%). The mesylate derivative was prepared in accordance with the procedure of Example 1 (9).
後処理
- custom, 19, 461 (1976)} were reacted
出典と根拠
- ORDレコード
- ord-9757eb78aaf243dd8b7402bab0cddbc6
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087606B2
関連ノート
読み込み中…