Methyl iodide → 1-methyl-2-(methylsulfanyl)-4,5-dihydro-1H-imidazole hydroiodide

HRID 80380ノート

反応式

HRID 80380 の反応式
[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[S:7].[CH3:8][I:9]>CC(C)=O>[IH:9].[CH3:1][N:2]1[CH2:6][CH2:5][N:4]=[C:3]1[S:7][CH3:8]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 2733224Methylethylenethiourea

生成物 1

HCID 122815051-methyl-2-(methylsulfanyl)-4,5-dihydro-1H-imidazole hydroiodide収率 77%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a suspension of 1-methylimidazolidine-2-thione (5.17 g, 44.5 mmol) in acetone (50 mL) was added MeI (2.9 mL, 46.6 mmol). The solution was allowed to stir at room temperature for 4 h and the resulting solid was quickly filtered and then dried in vacuo to give 1-methyl-2-(methylthio)-4,5-dihydro-1H-imidazole hydroiodide (8.79 g, 77%) as beige solid.

後処理

  1. filtrationthe resulting solid was quickly filtered
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-801cb7892fff46e38945eb854752d3b4
出典データセット
uspto-grants-2014_09
特許番号
US08846023B2

反応ノート

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