Hydrochloric Acid → 2-Acetamido-6-methylbenzoic acid

HRID 804

反応式

HRID 804 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([OH:10])=[O:9].[OH-].[Na+].[C:14](OC(=O)C)(=[O:16])[CH3:15].Cl>O>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH:11][C:14](=[O:16])[CH3:15])[C:7]=1[C:8]([OH:10])=[O:9]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 1512106-Methylanthranilic acid

生成物 1

HCID 28014002-Acetamido-6-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

90.6 g (0.6 mol) of 6-methylanthranilic acid are added to a solution of 24.8 g (0.62 mol) of NaOH in 500 ml of water and 63.4 g (0.62 mol) of acetic anhydride are then added dropwise. After stirring for one hour, the mixture is acidified to pH 3 with conc. HCl with cooling, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C.

後処理

  1. additionare then added dropwise
  2. temperaturewith cooling
  3. filtrationthe precipitate which deposits is filtered off with suction
  4. washwashed with water
  5. customdried under reduced pressure at 50° C.

出典と根拠

ORDレコード
ord-1754134a9e1b4ab5a610540df5e81abc
出典データセット
uspto-grants-1998_03
特許番号
US05723415

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