Potassium Carbonate → 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene
反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].CS([O-])(=O)=O.[CH2:17]([N:19]([CH2:24][CH3:25])[CH2:20][CH2:21][CH2:22]O)[CH3:18].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([O:11][CH2:22][CH2:21][CH2:20][N:19]([CH2:24][CH3:25])[CH2:17][CH3:18])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]参加物
6
実験手順
A solution of 3-fluoro-4-nitrophenol (2 mmol) and methanesulfonate of 3-diethylamino-1-propanol (2.5 mmol) in DMF (4 mL) is added with K2CO3 (4 mmol) and heated following the general procedure III (Step A). The product, 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene is obtained (470 mg) after purification using silica gel column chromatography.
後処理
- temperatureheated
出典と根拠
- ORDレコード
- ord-f375c00562a24af688c5e95063e27f6d
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087632B2
反応ノート
読み込み中…