Sodium Iodide → 4-Benzyloxy-2-fluoro-1-nitrobenzene

HRID 80519

反応式

HRID 80519 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:9][C:10]1[CH:11]=[C:12]([OH:19])[CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CC(C)=O>[CH2:2]([O:19][C:12]1[CH:13]=[CH:14][C:15]([N+:16]([O-:18])=[O:17])=[C:10]([F:9])[CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 5209483-Fluoro-4-nitrophenol

生成物 1

HCID 221807044-Benzyloxy-2-fluoro-1-nitrobenzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
55 °C

実験手順

(Bromomethyl)benzene (10.9 g, 63.7 mmol) and 3-fluoro-4-nitrophenol (10 g, 63.7 mmol) were added to 150 mL acetone followed by potassium carbonate (8.8 g, 63.7 mmol) and sodium iodide (9.54 g, 63.7 mmol). The reaction mixture was heated at 55° C. overnight. The resulting mixture was filtered and concentrated. The crude material was recrystallized in ethyl acetate/hexane to give the title compound. MS (DCI+) m/z 264.9 (M+NH4)+.

後処理

  1. filtrationThe resulting mixture was filtered
  2. concentrationconcentrated
  3. customThe crude material was recrystallized in ethyl acetate/hexane

出典と根拠

ORDレコード
ord-9602a878ebc942c498254a3c05a59c9e
出典データセット
uspto-grants-2014_09
特許番号
US08846663B2

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