Hydrochloric Acid → 6-Amino-2-methyl-3-nitrobenzoic acid

HRID 806

反応式

HRID 806 の反応式
[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([NH:14]C(=O)C)[C:3]=1[C:4]([OH:6])=[O:5].Cl>[OH-].[Na+]>[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([NH2:14])[C:3]=1[C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 152831716-Acetylamino-2-methyl-3-nitro-benzoic acid

生成物 1

HCID 152831726-Amino-2-methyl-3-nitrobenzoic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
95 °C

実験手順

450 ml of 2N NaOH are initially taken and 75.6 g (0.317 mol) of 2-methyl-3-nitro-6-acetamidobenzoic acid are added. The reaction mixture is then warmed to 95° C. and is stirred at this temperature for one hour. After cooling to 10° C., it is acidified by addition of 425 ml of 2N HCl, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C.

後処理

  1. temperatureAfter cooling to 10° C.
  2. filtrationthe precipitate which deposits is filtered off with suction
  3. washwashed with water
  4. customdried under reduced pressure at 50° C.

出典と根拠

ORDレコード
ord-36a2a540166a44e2ae3ef4e91516ef3a
出典データセット
uspto-grants-1998_03
特許番号
US05723415

関連ノート

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