Pyridine → 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 8063

反応式

HRID 8063 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][NH2:8].[CH2:9]([O:11][C:12](=[O:20])[CH:13]([C:17](=O)[CH3:18])[C:14](=O)[CH3:15])[CH3:10].N1C=CC=CC=1>C(O)C>[CH2:9]([O:11][C:12]([C:13]1[C:14]([CH3:15])=[N:8][N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:17]=1[CH3:18])=[O:20])[CH3:10]

参加物

5

反応物 3

HCID 1049PyridineHCID 786452-HydrazinopyridineHCID 79063Ethyl 2-acetylacetoacetate

生成物 1

HCID 98562563,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Similar to Example 1, 2-pyridylhydrazine (7.5 mmol, 0.8 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (7.5 mmol, 1.3 g) were mixed in a solution of 50% pyridine in ethanol, then heated under reflux. The solvents were removed under vacuum and the residue purified over silica. The named product crystallized upon standing (m.p. 49° C.–50° C.).

後処理

  1. temperatureheated
  2. temperatureunder reflux
  3. customThe solvents were removed under vacuum
  4. customthe residue purified over silica
  5. customThe named product crystallized

出典と根拠

ORDレコード
ord-d66dcc09bc84436bab5835d34320f478
出典データセット
uspto-grants-2006_08
特許番号
US07087634B2

関連ノート

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