3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester → 1-(3-Aminophenyl)-3,5-dimethyl-1h-pyrazole-4-carboxylic acid ethyl ester

HRID 8064

反応式

HRID 8064 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[CH:13]=2)[C:10]=1[CH3:11])=[O:5])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([NH2:18])[CH:13]=2)[C:10]=1[CH3:11])=[O:5])[CH3:2]

参加物

5

反応物 2

HCID 6569693,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 98138381-(3-Aminophenyl)-3,5-dimethyl-1h-pyrazole-4-carboxylic acid ethyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The compound of Example 2 (1.8 g) was dissolved in ethanol then 0.2 g 5% Pd/C was added to the solution. The mixture was treated with hydrogen gas at 45 psi. Upon completion of the reaction, the solution was filtered through Celite, and the filtrate concentrated under vacuum. The named product slowly crystallized upon standing (m.p. 93° C.–95° C.).

後処理

  1. customUpon completion of the reaction
  2. filtrationthe solution was filtered through Celite
  3. concentrationthe filtrate concentrated under vacuum
  4. customThe named product slowly crystallized

出典と根拠

ORDレコード
ord-7fc1f7aaa5b34943a693ad3861040cc8
出典データセット
uspto-grants-2006_08
特許番号
US07087634B2

関連ノート

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