Ammonium Chloride → 1-Methoxy-2-phenyl-pent-4-en-2-ol
反応式
[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH2:12]([Mg]Cl)[CH:13]=[CH2:14].[NH4+].[Cl-]>O1CCCC1>[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([OH:5])[CH2:14][CH:13]=[CH2:12]参加物
5
実験手順
2-Methoxy-1-phenyl-ethanone (5.00 g) dissolved in tetrahydrofuran (50 mL) was added to 2 M allylmagnesium chloride in tetrahydrofuran (21 mL) at room temperature. The solution was stirred at room temperature for 3 h and then 10% aqueous NH4Cl solution (50 mL) was added. The resulting mixture was extracted with tert-butyl methyl ether (3×50 mL) and the combined extracts were washed with water (50 mL) and brine (50 mL). The solvent was evaporated to afford the title compound as a colorless oil.
後処理
- extractionThe resulting mixture was extracted with tert-butyl methyl ether (3×50 mL)
- washthe combined extracts were washed with water (50 mL) and brine (50 mL)
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-8b50a2fcf3184d7c8fa0f2da8a70acba
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846668B2
反応ノート
読み込み中…