{2-[7-(2-Methanesulfonyl-vinyl)-1H-indol-3-yl)-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester → {2-[7-(2-methanesulfonyl-ethyl)-1H-indol-3-yl]-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester

HRID 8109ノート

反応式

HRID 8109 の反応式
[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]([CH3:26])([CH3:25])[CH2:9][C:10]1[C:18]2[C:13](=[C:14]([CH:19]=[CH:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]([CH3:26])([CH3:25])[CH2:9][C:10]1[C:18]2[C:13](=[C:14]([CH2:19][CH2:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)([CH3:3])([CH3:4])[CH3:2]

参加物

4

反応物 1

HCID 86595247{2-[7-(2-Methanesulfonyl-vinyl)-1H-indol-3-yl)-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester

生成物 1

HCID 69517243{2-[7-(2-methanesulfonyl-ethyl)-1H-indol-3-yl]-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester収率 80%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回

実験手順

To a solution of {2-[7-(2-methanesulfonyl-vinyl)-1H-indol-3-yl]-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester (0.40 g, 1.02,mmol) in methanol (20.0 mL) is added 10% Pd/C (0.10 g) in methanol (2.0 mL). The reaction mixture is purged with hydrogen and hydrogenation is carried out with a hydrogen balloon overnight. The reaction mixture is filtered and the filtrate is evaporated to dryness to give 320 mg of {2-[7-(2-methanesulfonyl-ethyl)-1H-indol-3-yl]-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester (80%). FDMS m/e=395.2 (M++1).

後処理

  1. customThe reaction mixture is purged with hydrogen and hydrogenation
  2. customis carried out with a hydrogen balloon overnight
  3. filtrationThe reaction mixture is filtered
  4. customthe filtrate is evaporated to dryness

出典と根拠

ORDレコード
ord-2b811ded5cc54bc39f20d5cd39b68575
出典データセット
uspto-grants-2006_08
特許番号
US07087635B2

反応ノート

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