Aluminium lithium hydride → HCID 178461264、化合物

HRID 81090ノート

反応式

HRID 81090 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].CC1C=CC(S([O:17][CH2:18][C@H:19]2[CH2:24][CH2:23][C@H:22]([CH2:25]O)[CH2:21][CH2:20]2)(=O)=O)=CC=1>C1COCC1>[CH3:25][C@H:22]1[CH2:23][CH2:24][C@H:19]([CH2:18][OH:17])[CH2:20][CH2:21]1

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 178427753HCID 178427753、化合物

生成物 1

HCID 178461264HCID 178461264、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

LiAlH4 (153 g, 4 mol) was added to a solution of trans-4-(hydroxymethyl)cyclohexylmethyl 4-methylbenzenesulfonate (400 g, 1.34 mol) in THF (3000 mL) at −20° C. The mixture was stirred at room temperature for 3 h. It was quenched with water (10 L) and filtered. The filtrate was concentrated in vacuo to give trans-(4-methylcyclohexyl)methanol.

後処理

  1. customIt was quenched with water (10 L)
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-0228a5c2343142b8acb69529573249d1
出典データセット
uspto-grants-2014_09
特許番号
US08846657B2

反応ノート

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