Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate → 4-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine

HRID 81136ノート

反応式

HRID 81136 の反応式
[CH3:1][O:2][CH:3]1[CH2:7][N:6](C(OCC2C=CC=CC=2)=O)[CH:5]([C:18]2([O:21][CH3:22])[CH2:20][CH2:19]2)[CH2:4]1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][CH:3]1[CH2:7][NH:6][CH:5]([C:18]2([O:21][CH3:22])[CH2:20][CH2:19]2)[CH2:4]1

参加物

5

反応物 2

HCID 86724494Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 867244954-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate (141 mg, 0.462 mmol) dissolved in ethyl acetate (3.1 mL) was added palladium on carbon (49.1 mg, 0.05 mmol). Hydrogen gas was added via balloon and the reaction was stirred at room temperature for 3 hours. The mixture was filtered over celite and concentrated under reduced pressure to afford 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine.

後処理

  1. filtrationThe mixture was filtered over celite and
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-42d9d219fb804727a47f3f298fb60684
出典データセット
uspto-grants-2014_09
特許番号
US08846657B2

反応ノート

読み込み中…