HCID 178525710、化合物 → HCID 178520945、化合物
反応式
[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](O)=[O:10])[CH2:5][CH2:4]1>C1COCC1>[F:1][C:2]([F:12])([F:13])[C@H:3]1[CH2:4][CH2:5][C@H:6]([CH2:9][OH:10])[CH2:7][CH2:8]1参加物
3
実験手順
BH3 (100 mL, 0.1 mol, 1.0 M solution in THF) was added dropwise to 0° C. solution of trans-4-(trifluoromethyl)cyclohexanecarboxylic acid (19.6 g, 0.1 mol) in dry THF (100 mL). The reaction was stirred at room temperature for 5 h, quenched with water, extracted with EtOAc, washed with brine, dried over Na2SO4, filtered, and concentrated to give [trans-4-(trifluoromethyl)cyclohexyl]methanol. 1H NMR (300 MHz, CDCl3): δ 3.48-3.47 (d, 2H), 2.00-1.89 (m, 5H), 1.51-1.43 (m, 1H), 1.35-1.26 (m, 2H), 1.05-0.96 (m, 2H).
後処理
- customquenched with water
- extractionextracted with EtOAc
- washwashed with brine
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5f33ae438b93447eacece0ab20229db9
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846657B2
反応ノート
読み込み中…