rel-Phenylmethyl (3R,4R)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methoxy-1-piperidinecarboxylate → HCID 58522529、化合物
反応式
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][N:12](C(OCC2C=CC=CC=2)=O)[CH2:11][C@H:10]1[O:25][CH3:26])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:7])[NH:8][C@@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[O:25][CH3:26])([CH3:4])([CH3:3])[CH3:2]参加物
4
実験手順
Benzyl (3R,4R)-4-tert-butoxycarbonylamino-3-methoxy-piperidine-1-carboxylate (2.88 g) is dissolved in ethanol and combined with a spatula tip of Pd/C and hydrogenated under H2 pressure (4 bar). After 18 h the catalyst is filtered off and the solvent is eliminated in vacuo. The residue is used in the next reaction step without any further purification.
後処理
- filtrationAfter 18 h the catalyst is filtered off
- customThe residue is used in the next reaction step without any further purification
出典と根拠
- ORDレコード
- ord-51589e2bcc7d431d84f52fe30b050afd
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846689B2
反応ノート
読み込み中…