Hydrochloric Acid → (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine
反応式
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][CH2:5][C@H:6]1[CH2:10][C@H:9]([F:11])[CH2:8][N:7]1C(OC(C)(C)C)=O.Cl.C(=O)([O-])O.[Na+]>C1COCC1>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][CH2:5][C@H:6]1[CH2:10][C@H:9]([F:11])[CH2:8][NH:7]1参加物
5
実験手順
7.7 2.5 g of tert-butyl (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine-1-carboxylate are dissolved in 20 ml of THF and stirred at 80° C. for 2 h with 5 ml of ethanolic hydrochloric acid. After basic work-up using saturated sodium hydrogencarbonate solution, the organic phase is subjected to conventional work-up, and the residue obtained is purified by chromatography, giving 780 mg of (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine as brown oil; Rt.: 0.700 min; [M+H]+230.2.
後処理
- customthe residue obtained
- customis purified by chromatography
出典と根拠
- ORDレコード
- ord-8ec2275089e44ab09fec2df629e6515a
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846694B2
反応ノート
読み込み中…