Tetrahydrofuran → 2-[(3,4-Dichloro-5-fluoro-phenyl)-hydroxy-methyl]-2-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester

反応式

[C:12]([CH3:13])([CH3:14])([CH3:15])[O:16][C:17](=[O:18])[N:19]1[C:20]([CH2:24][CH2:25][CH3:26])([CH:27]=[O:28])[CH2:21][CH2:22][CH2:23]1.[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[Cl:1][c:2]1[cH:3][c:4]([Br:10])[cH:5][c:6]([F:9])[c:7]1[Cl:8].[Mg:11]>>[Cl:1][c:2]1[cH:3][c:4]([CH:27]([C:20]2([CH2:24][CH2:25][CH3:26])[N:19]([C:17]([O:16][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:18])[CH2:23][CH2:22][CH2:21]2)[OH:28])[cH:5][c:6]([F:9])[c:7]1[Cl:8]