Sodium Carbonate → (3-Amino-6-bromo-pyrazin-2-yl)-pyridin-3-yl-methanone

HRID 81474

反応式

HRID 81474 の反応式
[NH2:1][C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.C([O-])([O-])=O.[Na+].[Na+].[Br:22]Br>C(O)(=O)C>[NH2:1][C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][C:5]([Br:22])=[CH:6][N:7]=1

参加物

5

反応物 3

HCID 10340Sodium Carbonate2 回HCID 24408Bromine2 回HCID 68630652(3-Amino-pyrazin-2-yl)-pyridin-3-yl-methanone

生成物 1

HCID 86634541(3-Amino-6-bromo-pyrazin-2-yl)-pyridin-3-yl-methanone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒3 回

実験手順

(3-Amino-pyrazin-2-yl)-pyridin-3-yl-methanone (1.00 g, 4.99 mmol) is dissolved in glacial acetic acid (10 ml). Na2CO3 (0.583 g, 5.49 mmol) is added. After evolution of gas has finished, a solution of bromine (0.192 ml, 3.74 mmol) in acetic acid (5 ml) is added dropwise. Na2CO3 (0.583 mg, 5.49 mmol) is added, followed by a second solution of bromine (0.192 ml, 3.74 mmol) in acetic acid (5 ml). The resulting orange suspension is left to stir for 1 hour. The reaction is quenched by pouring onto ice water (150 ml), and the orange solid formed is collected by filtration, washed with water and dried in vacuo at 40° C. overnight to yield the title compound. [M+H]+ 279.

後処理

  1. waitThe resulting orange suspension is left
  2. customThe reaction is quenched
  3. additionby pouring onto ice water (150 ml)
  4. customthe orange solid formed
  5. filtrationis collected by filtration
  6. washwashed with water
  7. customdried in vacuo at 40° C. overnight

出典と根拠

ORDレコード
ord-2df8dadc6d6444069182564d5bc89b78
出典データセット
uspto-grants-2014_09
特許番号
US08846687B2

関連ノート

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