Sodium Hydroxide → (2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone

HRID 81488ノート

反応式

HRID 81488 の反応式
CC(C)(C)C([NH:5][C:6]1[C:11]([C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:10][CH:9]=[CH:8][N:7]=1)=O.[OH-].[Na+]>Cl>[NH2:5][C:6]1[C:11]([C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:10][CH:9]=[CH:8][N:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 686311822,2-dimethyl-N-[3-(pyridine-3-carbonyl)-pyridin-2-yl]-propionamide

生成物 1

HCID 53678495(2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 2,2-dimethyl-N-[3-(pyridine-3-carbonyl)-pyridin-2-yl]-propionamide (0.225 g, 0.79 mmol) in 3M HCl (10 ml) is heated at reflux for 4 hours. The reaction mixture is allowed to cool to room temperature and the pH adjusted to basic with 2M NaOH. The product is extracted into DCM, dried (MgSO4), and concentrated in vacuo to afford a yellow solid. Drying in vacuo at 45° C. overnight yields (2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone [M+H]+ 200.

後処理

  1. temperatureat reflux for 4 hours
  2. extractionThe product is extracted into DCM
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customto afford a yellow solid
  6. customDrying in vacuo at 45° C. overnight

出典と根拠

ORDレコード
ord-3147b6d8ef0a4ebe9c6078be1d95b6ee
出典データセット
uspto-grants-2014_09
特許番号
US08846687B2

反応ノート

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