Water → 5-Bromo-3-chloropyrazin-2-amine

HRID 81495

反応式

HRID 81495 の反応式
[Cl:1][C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][N:7]=1.C(=O)([O-])[O-].[Na+].[Na+].[Br:15]Br.O>C(O)(=O)C>[Br:15][C:6]1[N:7]=[C:2]([Cl:1])[C:3]([NH2:8])=[N:4][CH:5]=1

参加物

6

反応物 4

HCID 962WaterHCID 10340Sodium Carbonate2 回HCID 24408Bromine2 回HCID 2762242-Amino-3-chloropyrazine

生成物 1

HCID 467382025-Bromo-3-chloropyrazin-2-amine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒3 回

実験手順

3-Chloro-pyrazin-2-ylamine (0.750 g, 5.79 mmol) is suspended in acetic acid (7 ml) with stirring at room temperature and sodium carbonate (0.675 g, 6.37 mmol) is added. When all the gas has evolved bromine (0.171 ml, 3.34 mmol) in acetic acid (4 ml) is added dropwise. Sodium carbonate (0.675 g, 6.37 mmol) is added and a gas evolves. Once all gas has evolved bromine (0.171 ml, 3.34 mmol) in acetic acid (4 ml) is added. The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is poured onto iced water and left to stir for 30 minutes. A pale yellow suspension has formed. This solid is filtered off and rinsed with cold water to give 5-Bromo-3-chloro-pyrazin-2-ylamine.

後処理

  1. additionis added dropwise
  2. additionis added
  3. stirringThe reaction mixture is stirred at room temperature for 1 hour
  4. waitleft
  5. stirringto stir for 30 minutes
  6. customA pale yellow suspension has formed
  7. filtrationThis solid is filtered off
  8. washrinsed with cold water

出典と根拠

ORDレコード
ord-6070ba6a7f884eb59c1475f9ac09e9a1
出典データセット
uspto-grants-2014_09
特許番号
US08846687B2

関連ノート

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