Ethyl bromoacetate → (2-Isopropyl-4-methoxy-5-methyl-phenoxy)-acetic acid ethyl ester

HRID 81763ノート

反応式

HRID 81763 の反応式
[CH:1]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([CH3:12])=[CH:6][C:5]=1[OH:13])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>CC(C)=O>[CH2:25]([O:24][C:22](=[O:23])[CH2:21][O:13][C:5]1[CH:6]=[C:7]([CH3:12])[C:8]([O:10][CH3:11])=[CH:9][C:4]=1[CH:1]([CH3:3])[CH3:2])[CH3:26]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 2515102-Isopropyl-4-methoxy-5-methyl-phenol

生成物 1

HCID 59598614(2-Isopropyl-4-methoxy-5-methyl-phenoxy)-acetic acid ethyl ester収率 82.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 2-isopropyl-4-methoxy-5-methyl-phenol (3.933 g, 21.8 mmol) in acetone (100 ml) was added potassium carbonate (20 g, 145 mmol) and ethyl bromoacetate (5 ml, 45.1 mmol). The mixture refluxed over night and was filtered through celite. The filtrate was concentrated under reduced pressure and the residue was partitioned between ethyl acetate and water. The organic phase was washed with brine and dried over anhydrous sodium sulfate. After removal of drying agent, the organic solution was concentrated under reduced pressure. The residue was purified with silica gel chromatography (10% to 15% methylene chloride in hexane) to yield (2-isopropyl-4-methoxy-5-methyl-phenoxy)-acetic acid ethyl ester as white solid (4.78 g, 82%).

後処理

  1. temperatureThe mixture refluxed over night
  2. filtrationwas filtered through celite
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe residue was partitioned between ethyl acetate and water
  5. washThe organic phase was washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customAfter removal
  8. customof drying agent
  9. concentrationthe organic solution was concentrated under reduced pressure
  10. customThe residue was purified with silica gel chromatography (10% to 15% methylene chloride in hexane)

出典と根拠

ORDレコード
ord-bb558d8b908a4fc0b56ad3da0614ddd2
出典データセット
uspto-grants-2014_09
特許番号
US08846705B2

反応ノート

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