Water → 5-Bromo-3,4-dihydroxybenzaldehyde

HRID 81795

反応式

HRID 81795 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].[Br:11]Br.O>CC(O)=O>[Br:11][C:8]1[CH:7]=[C:4]([CH:3]=[C:2]([OH:1])[C:9]=1[OH:10])[CH:5]=[O:6]

参加物

5

反応物 3

HCID 962WaterHCID 87683,4-DihydroxybenzaldehydeHCID 24408Bromine

生成物 1

HCID 854055-Bromo-3,4-dihydroxybenzaldehyde収率 48%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a solution of 3,4-dihydroxy benzaldehyde (15.48 g, 112 mmol) in 500 ml AcOH was added bromine (6.1 ml, 118 mmol) drop-wise in 50 ml AcOH over 10 min. After 4 h the mixture was poured into cold H2O. The precipitate was filtered, washed with cold H2O and dried in vacuum to give 3-bromo-4,5-dihydroxy-benzaldehyde (11.64 g, 48%) as a grey solid.

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed with cold H2O
  3. customdried in vacuum

出典と根拠

ORDレコード
ord-2a2d7a032d404c9d80a6dad6c2b94dbf
出典データセット
uspto-grants-2014_09
特許番号
US08846705B2

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