Pyridine → Ethanone, 2-(acetyloxy)-1-phenyl-

HRID 8191

反応式

HRID 8191 の反応式
[OH:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].N1C=CC=CC=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:2][O:1][C:17](=[O:19])[CH3:18]

参加物

6

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 68490alpha-Hydroxyacetophenone

生成物 1

HCID 222851Ethanone, 2-(acetyloxy)-1-phenyl-

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.

後処理

  1. washThe mixture is washed with water (200 mL) and brine (200 mL)
  2. dry with materialthen dried over sodium sulfate
  3. filtrationThe mixture is filtered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0a2ba70e58064169870e248f2da8307c
出典データセット
uspto-grants-2006_08
特許番号
US07087626B2

関連ノート

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