Piperidine → 1-(4-Iodobenzoyl)piperidine

HRID 82038

反応式

HRID 82038 の反応式
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>ClCCl>[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:7])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 8082PiperidineHCID 743734-Iodobenzoyl chloride

生成物 1

HCID 51492041-(4-Iodobenzoyl)piperidine収率 100.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 4-iodo-benzoyl chloride (2.00 g, 7.51 mmol) in dichloromethane (25 mL) was added piperidine (1.85 mL, 18.76 mmol). The reaction mixture was heated at reflux for 1.5 hour and then cooled to room temperature. The organic layer was washed with an aqueous 1M HCl solution, brine, dried (Na2SO4), filtered, concentrated under vacuum to give the title compound (2.37 g, 100%) as a white solid.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 1.5 hour
  3. washThe organic layer was washed with an aqueous 1M HCl solution, brine
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-76702ff425514fff805c099782e85379
出典データセット
uspto-grants-2014_09
特許番号
US08846712B2

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