Piperidine → 1-(4-Iodobenzoyl)piperidine
反応式
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>ClCCl>[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:7])=[CH:4][CH:3]=1参加物
4
実験手順
To a suspension of 4-iodo-benzoyl chloride (2.00 g, 7.51 mmol) in dichloromethane (25 mL) was added piperidine (1.85 mL, 18.76 mmol). The reaction mixture was heated at reflux for 1.5 hour and then cooled to room temperature. The organic layer was washed with an aqueous 1M HCl solution, brine, dried (Na2SO4), filtered, concentrated under vacuum to give the title compound (2.37 g, 100%) as a white solid.
後処理
- temperatureThe reaction mixture was heated
- temperatureat reflux for 1.5 hour
- washThe organic layer was washed with an aqueous 1M HCl solution, brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-76702ff425514fff805c099782e85379
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846712B2
反応ノート
読み込み中…