Acetic Acid → 1-(Chloromethyl)-4-fluoronaphthalene
反応式
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.C=O.P(=O)(O)(O)O.[ClH:19].[C:20](O)(=O)C>O>[Cl:19][CH2:20][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([F:1])=[CH:3][CH:4]=1参加物
7
実験手順
A solution of 1-fluoronaphthalene (5.5 g, 37.6 mmol), paraformaldehyde (2.5 g, 83 mmol), glacial acetic acid (3.5 mL), phosphoric acid (2 mL) and concentrated hydrochloric acid (5 mL) is heated at 85° C. for 15 h. The reaction mixture is poured into water and extracted three times with dichloromethane. The organic extracts are combined and washed with water and brine, dried (sodium sulfate), filtered, and evaporated to yield the title compound, 6.53 g (98%, as a yellow solid.
後処理
- extractionextracted three times with dichloromethane
- washwashed with water and brine
- dry with materialdried (sodium sulfate)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-eb6b605148f94f1c8e3a24b3c564aca0
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087626B2
反応ノート
読み込み中…