Thionyl Chloride → 4-(chloromethyl)-1-isopropyl-5-(trifluoromethyl)-1H-pyrazole
反応式
S(Cl)([Cl:3])=O.[CH:5]([N:8]1[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([CH2:17]O)[CH:10]=[N:9]1)([CH3:7])[CH3:6]>C(Cl)Cl>[Cl:3][CH2:17][C:11]1[CH:10]=[N:9][N:8]([CH:5]([CH3:7])[CH3:6])[C:12]=1[C:13]([F:16])([F:15])[F:14]参加物
4
実験手順
Thionyl chloride (5.26 mL, 72 mmol) was added to [1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methanol (Preparation 183, 7.5 g, 36 mmol) in DCM (75 mL) at 0° C. and the mixture was stirred for 2 hours. The mixture was diluted with DCM (30 mL) and the organic phase was washed with water (75 mL), brine (75 mL) and dried over sodium sulphate. The filtrate was evaporated in vacuo to afford 4-(chloromethyl)-1-isopropyl-5-(trifluoromethyl)-1H-pyrazole in 86% yield, 7 g.
後処理
- washthe organic phase was washed with water (75 mL), brine (75 mL)
- dry with materialdried over sodium sulphate
- customThe filtrate was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-db770f9f3e0041fb8531c2a83e9ab379
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846698B2
反応ノート
読み込み中…