Ethanol → Ethyl 4-nitrophenylacetate

HRID 82287

反応式

HRID 82287 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].S(=O)(=O)(O)O.[OH-].[Na+].[CH2:21](O)[CH3:22]>>[CH2:21]([O:12][C:11](=[O:13])[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)[CH3:22]

参加物

5

反応物 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 4661(4-Nitrophenyl)acetic acidHCID 14798Sodium Hydroxide

生成物 1

HCID 79517Ethyl 4-nitrophenylacetate収率 98%

実験手順

To a stirred solution of (4-nitro-phenyl)-acetic acid (3 g, 16.4 mmol) in ethanol (30 mL) was added sulphuric acid (1 mL) and the reaction mixture was heated to reflux for 16 hours. The reaction mixture was neutralized with 2N aq. NaOH solution and extracted with EtOAc (3×50 mL). The combined organic layers were dried (Na2SO4) and evaporated in vacuo to afford the title compound as a light yellow oil in 98% yield, 3.4 g.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 16 hours
  3. extractionextracted with EtOAc (3×50 mL)
  4. dry with materialThe combined organic layers were dried (Na2SO4)
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-6b9f9ab498404a8ab71a0ea8bcffc870
出典データセット
uspto-grants-2014_09
特許番号
US08846698B2

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