Lithium Hydroxide → HCID 86672138、化合物
反応式
[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([C:10]([O:12]CC)=[O:11])[CH:5]=1.[Li+].[OH-]>CO>[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([C:10]([OH:12])=[O:11])[CH:5]=1参加物
4
実験手順
To a solution of ethyl 5-(methoxymethyl)-1-methyl-1H-pyrazole-3-carboxylate (WO9743277) (177 mg, 0.893 mmol) in MeOH, a 0.5 M solution of LiOH was added (5.3 mL, 2.68 mmol). The reaction was stirred at room temperature overnight. The solution was evaporated to dryness and the residue was adjusted to pH5 with a 2 N HCl solution. The aqueous solution was extracted with EtOAc and the organic layer was dried over Na2SO4 and evaporated in vacuo to give the title compound as a white solid 95%, 145 mg.
後処理
- customThe solution was evaporated to dryness
- extractionThe aqueous solution was extracted with EtOAc
- dry with materialthe organic layer was dried over Na2SO4
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-f7b2a6feb4c7410d84bd9f7e300efde1
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846698B2
反応ノート
読み込み中…