Cyclopentylamine → 4-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline-7-carboxylic Acid Cyclopentylamide

HRID 8256

反応式

HRID 8256 の反応式
Cl.CN(C)CCCN=C=NCC.C1C=CC2N(O)N=NC=2C=1.[CH:23]1([NH2:28])[CH2:27][CH2:26][CH2:25][CH2:24]1.[N:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]1[C:36]([C:43]2[C:52]3[C:47](=[CH:48][C:49]([C:53](O)=[O:54])=[CH:50][CH:51]=3)[N:46]=[CH:45][CH:44]=2)=[C:37]2[CH2:42][CH2:41][CH2:40][N:38]2[N:39]=1>ClCCl>[CH:23]1([NH:28][C:53]([C:49]2[CH:48]=[C:47]3[C:52]([C:43]([C:36]4[C:35]([C:30]5[CH:31]=[CH:32][CH:33]=[CH:34][N:29]=5)=[N:39][N:38]5[CH2:40][CH2:41][CH2:42][C:37]=45)=[CH:44][CH:45]=[N:46]3)=[CH:51][CH:50]=2)=[O:54])[CH2:27][CH2:26][CH2:25][CH2:24]1

参加物

6

反応物 4

HCID 2906CyclopentylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 219924874-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline-7-carboxylic Acid

生成物 1

HCID 101371304-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline-7-carboxylic Acid Cyclopentylamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, (53 mg, 0.30 mmol), HOBT, (24 mg, 0.28 mmol), cyclopentylamine (0.03 mL, 0.30 mmol), and 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline-7-carboxylic acid (90 mg, 0.25 mmol) in dichloromethane (1 mL) is stirred room temperature for 18 h. The mixture is concentrated in vacuo and the residue chromatographed on SiO2 to yield the title compound, 31 mg (31%,) as a white solid.

後処理

  1. concentrationThe mixture is concentrated in vacuo
  2. customthe residue chromatographed on SiO2

出典と根拠

ORDレコード
ord-7e43ca3ac0294abfb9cc8c732e641078
出典データセット
uspto-grants-2006_08
特許番号
US07087626B2

関連ノート

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