N-benzyl-N-methyl-3-nitropyridin-2-amine → 2-N-methylpyridine-2,3-diamine

HRID 82583ノート

反応式

HRID 82583 の反応式
[CH2:1]([N:8](C)[C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>CCO.[Pd]>[CH3:1][NH:8][C:9]1[C:14]([NH2:15])=[CH:13][CH:12]=[CH:11][N:10]=1

参加物

4

反応物 1

HCID 9211491N-benzyl-N-methyl-3-nitropyridin-2-amine

生成物 1

HCID 123436692-N-methylpyridine-2,3-diamine収率 92.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of N-benzyl-N-methyl-3-nitropyridin-2-amine (15 g) and 10% Pd—C (6.56 g) in EtOH (300 mL) was hydrogenated under balloon pressure at room temperature over weekend. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give N2-methylpyridine-2,3-diamine (7.00 g) as a tan solid.

後処理

  1. waitwas hydrogenated under balloon pressure at room temperature over weekend
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-5101b913b3e247cca4f69c2fa01188fe
出典データセット
uspto-grants-2014_09
特許番号
US08846713B2

反応ノート

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