反応式
[F:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:5]=[CH:4][N:3]=1.[C:15]([O-])([O-])=O.[K+].[K+].CI>>[F:1][C:2]1[C:7]([C:8]([O:10][CH3:15])=[O:9])=[C:6]([C:11]([F:12])([F:13])[F:14])[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
To a mixture of 2-fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid (1.06 g) and K2CO3 (0.701 g) in DMF(dry) (10 mL) was added MeI (0.317 ml). The mixture was stirred at room temperature for 3 h. The mixture was directly purified by column chromatography (silica gel, EtOAc/hexane) to give the title compound (1.13 g, containing EtOAc and hexane, ca. 75% purity).
後処理
- customThe mixture was directly purified by column chromatography (silica gel, EtOAc/hexane)
出典と根拠
- ORDレコード
- ord-6302aff528d24ad7b6dc61b4c1fada97
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846713B2
関連ノート
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