化工社化工社 化学情報印刷レポート · 研究参考用
Benzene → 2-(4-Methoxymethoxyphenyl)-5,5-dimethyl-1,3-dioxane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | Neopentyl glycol | HCID 31344 | — |
| 反応物 | 4-(Methoxymethoxy)benzaldehyde | HCID 250074 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(4-Methoxymethoxyphenyl)-5,5-dimethyl-1,3-dioxane | HCID 9942983 | — |
反応手順
A solution of 4-methoxymethoxybenzaldehyde, neopentyl glycol (10.3 g, 98.9 mmol), pyridinium para-toluenesulfonate (1.0 g, 3.98 mmol), and benzene (500 ml) was refluxed with azeotropic removal of water for several hours, under argon. The cooled reaction mixture was quenched with 2 ml of triethylamine, and concentrated on rotary evaporator. The product was chromatographed (silica gel, 5% ethyl acetate in hexanes), yielding about 14.83 g of the product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846735B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-ffbd58b7353f45b0ba190e0fd9c8f074 |
| 出典メモ | uspto-grants-2014_09 |