反应详情

A solution of 4-methoxymethoxybenzaldehyde, neopentyl glycol (10.3 g, 98.9 mmol), pyridinium para-toluenesulfonate (1.0 g, 3.98 mmol), and benzene (500 ml) was refluxed with azeotropic removal of water for several hours, under argon. The cooled reaction mixture was quenched with 2 ml of triethylamine, and concentrated on rotary evaporator. The product was chromatographed (silica gel, 5% ethyl acetate in hexanes), yielding about 14.83 g of the product.

1. customThe cooled reaction mixture
2. customwas quenched with 2 ml of triethylamine
3. concentrationconcentrated on rotary evaporator
4. customThe product was chromatographed (silica gel, 5% ethyl acetate in hexanes)