Bromide ion → 4-(4-Chloro-phenyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

反応式

[Br-:1].[C:4]([CH3:5])([CH3:6])([CH3:7])[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH2:13][C:14]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)([C:24]([CH3:25])=[O:26])[CH2:15][CH2:16]1.[CH3:2][Mg+:3].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1.[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1.[c:32]1([CH3:33])[cH:34][cH:35][cH:36][cH:37][cH:38]1>>[CH3:2][C:24]([C:14]1([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH2:13][CH2:12][N:11]([C:9]([O:8][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:10])[CH2:16][CH2:15]1)([CH3:25])[OH:26]