Nitrogen → HCID 67958123、化合物

HRID 82838ノート

反応式

HRID 82838 の反応式
N#N.[Cl:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([CH2:10][OH:11])[N:9]=1.[CH3:12]I>C(Cl)Cl>[Cl:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([CH2:10][O:11][CH3:12])[N:9]=1

参加物

5

反応物 3

HCID 947NitrogenHCID 6328Methyl iodideHCID 67958068(2-(Chloromethyl)oxazol-4-yl)methanol

生成物 1

HCID 67958123HCID 67958123、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of (2-(chloromethyl)oxazol-4-yl)methanol (8.00 g, 54.22 mmol) in CH2Cl2 (32.0 mL) was treated with MeI (4.05 mL, 65.06 mmol) followed by Ag2O (18.85 g, 81.32 mmol) and the resulting mixture (protected from light) was stirred overnight at 40° C. The reaction mixture was filtered and the solvent was removed under reduced pressure. Purification of the residue by FC (6:4 hept-EA) gave the title compound as a yellow oil: TLC: rf (6:4 hept-EA)=0.31. LC-MS-conditions 07: tR=0.54 min, [M+H]+=162.00.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent was removed under reduced pressure
  3. customPurification of the residue by FC (6:4 hept-EA)

出典と根拠

ORDレコード
ord-4b5f3d8df14e4c57b6688740bca9f124
出典データセット
uspto-grants-2014_09
特許番号
US08846733B2

反応ノート

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