HCID 57467306、化合物 → Tert-butyl [7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate

HRID 82863ノート

反応式

HRID 82863 の反応式
[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]#[N:19])[CH:16]=2)[CH2:11][CH2:10][CH:9]1[NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.N.[Ni]>[NH2:19][CH2:18][C:15]1[CH:16]=[C:17]2[C:12]([CH2:11][CH2:10][CH:9]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH:8]2[CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:13][CH:14]=1

参加物

5

反応物 1

HCID 57467306HCID 57467306、化合物

生成物 1

HCID 57471193Tert-butyl [7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate収率 100.4%

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 222Ammonia溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

tert-Butyl 1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1.787 g, 4.93 mmol) was dissolved in THF (40 mL) and 7 N methanolic ammonia (40 mL). Raney nickel (0.422 g, 4.93 mmol) was added. The vessel was evacuated and filled with Hydrogen at atmospheric pressure. The mixture was stirred overnight at room temperature. The catalyst was filtered off on a celite pad and washed with 500 mL MeOH. Product was obtained as a crimson powder (1.813 g, 4.95 mmol, 100%) after evaporating the solvent.

後処理

  1. customThe vessel was evacuated
  2. additionfilled with Hydrogen at atmospheric pressure
  3. filtrationThe catalyst was filtered off on a celite pad
  4. washwashed with 500 mL MeOH

出典と根拠

ORDレコード
ord-6cf86237fda544c1a2ce561a2ddc0aac
出典データセット
uspto-grants-2014_09
特許番号
US08846741B2

反応ノート

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