Methanesulfonyl chloride → 1-(Diphenylmethyl)azetidin-3-yl methanesulfonate

HRID 82914

反応式

HRID 82914 の反応式
[C:1]1([CH:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:8]2[CH2:11][CH:10]([OH:12])[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>N1C=CC=CC=1>[CH3:19][S:20]([O:12][CH:10]1[CH2:11][N:8]([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:9]1)(=[O:22])=[O:21]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 3304481-(Diphenylmethyl)azetidin-3-ol

生成物 1

HCID 27587161-(Diphenylmethyl)azetidin-3-yl methanesulfonate収率 96.5%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
-20 °C

実験手順

A 100 mL flask was charged with 1-diphenylmethylazetidin-3-ol (1.5 g, 6.27 mmol) and pyridine (15 mL). The solution was cooled to −20° C. and methane sulfonyl chloride (0.73 mL, 9.4 mmol) was added dropwise. The reaction mixture was stirred at −20° C. for 1 h and then left 3 days at 4° C. The solution was poured on ice and the resulting precipitate was filtered, washed 3 times with H2O and 3 times with pentane. The solid was dried under reduced pressure to give the title compound (1.92 g, 96%) as a white solid.

後処理

  1. waitleft 3 days at 4° C
  2. additionThe solution was poured on ice
  3. filtrationthe resulting precipitate was filtered
  4. washwashed 3 times with H2O and 3 times with pentane
  5. customThe solid was dried under reduced pressure

出典と根拠

ORDレコード
ord-9a1bde83ffcd4def8f7bb5e71f141f7a
出典データセット
uspto-grants-2014_09
特許番号
US08846711B2

関連ノート

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